ProCon: localization and visualization of Protein Conservation

ProCon is tool for locating and visualization of evolutionary conservation in protein sequences. The method can identify three types of conservation: identity (type I), physicochemical similarity (II), and covariant conservation (III). The conservative sites of type I and II are located with entropy calculation and the third type is identified by calculation of mutual information. The interacting networks formed by covariant pairs can also be identified. All the three types of conservation can be visualized in a representative protein structure. The tool performs exhaustive analysis results of which can be used e.g. for identifying different types of conserved residues, studying protein-protein interactions, explaining consequences of disease-causing mutations and mutant design for protein engineering.

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how to use the predictor
Download ProCon Java Program
Software of ProCon in Java (runnable on Windows or MacOS Lion): download
We also have a mirror in Lund University: mirror link

Download ProCon Python Package
ProCon Python package for Python 3: download
Userguide (pdf document): download
You need to install graphviz program and python package in advance to use some functions.
For Windows, please download installation program in this page: download
For Linux, please use sudo apt-get install graphviz