ProCon: localization and visualization of Protein Conservation

ProCon is tool for locating and visualization of evolutionary conservation in protein sequences. The method can identify three types of conservation: identity (type I), physicochemical similarity (II), and covariant conservation (III). The conservative sites of type I and II are located with entropy calculation and the third type is identified by calculation of mutual information. The interacting networks formed by covariant pairs can also be identified. All the three types of conservation can be visualized in a representative protein structure. The tool performs exhaustive analysis results of which can be used e.g. for identifying different types of conserved residues, studying protein-protein interactions, explaining consequences of disease-causing mutations and mutant design for protein engineering.

Upload file Download About Disclaimer


This non-profit server, its associated data and services are for research purposes only. The responsibility of School of Computer Science and Technology, Soochow University is limited to applying the best efforts in providing and publishing good programs and data. The developers have no responsibility for the usage of results, data or information which this server has provided.


In preparation of this site and service, every effort has been made to offer the most current and correct information possible. We render no warranty, express or implied, as to its accuracy or that the information is fit for a particular purpose, and will not be held responsible for any direct, indirect, putative, special, or consequential damages arising out of any inaccuracies or omissions. In utilizing this service, individuals, organizations, and companies absolve Soochow University or any of their employees or agents from responsibility for the effect of any process, method or product or that may be produced or adopted by any part, notwithstanding that the formulation of such process, method or product may be based upon information provided here.