Basic information

Biomarker: miR-142-3p

Histology type: endometrial carcinoma

Cohort characteristics

Country: China

Region: Nanjing

Followed up time :

Subgroup 1 name : training stage EC

Subgroup 1 number: 22

Subgroup 2 name: training stage controls

Subgroup 2 number: 22

Cohort statistics: cutoff<50;cutoff>50

Total number Group I Group I number Group II Group II number Group III Group III number Group IV Group IV number
172 endometrial cancer 93 healthy 79

Sample information

Description: A signature consisting of 3 plasma miRNAs was identified and showed potential for the non-invasive diagnosis of EC.

Sample type : plasma

Sample method: qRT-PCR

Expression pattern : Ct-value < 37, 1.5-fold altered expression in EC patients compared with healthy controls

Expression elevation: The expression of miRNAs in plasma or exosomes was calculated using the 2−∆∆Ct method (cel-miR-39 as exogenous reference miRNA for plasma samples; RNU6B (U6) [U6] for tissue sample normalization; ∆Ct = Ct miRNA − Ct normalizer; Ct: the threshold cycle)

Disease information

Cohort age: 21;23

Subgroup 1 age: 8;24

Subgroup 2 age: 13;9

Related information

HGNC miRNA approved symbol: MIR142

HGNC miRNA approved name: microRNA 142

HGNC miRNA locus type: RNA, micro

HGNC miRNA symbol status: Approved

HGNC miRNA ID: HGNC:31529

HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31529

Stem loop sequence symbol: hsa-mir-142

Stem loop sequence accession: MI0000458

Stem loop sequence gene family: MIPF0000084

Stem loop sequence annotation confidence: high

Mature sequence symbol: hsa-miR-142-5p$hsa-miR-142-3p

Mature sequence accession: MIMAT0000433 $MIMAT0000434

Evidence: experimental; cloned [PMID:15325244,PMID:17604727]$experimental; cloned [PMID:14573789,PMID:15325244, PMID:17604727]

miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000458

Visulization