Basic information
Biomarker: miRNA 27a
Histology type: endometrioid endometrial carcinoma
Cohort characteristics
Region: Shatby Alexandria
Followed up time :
Subgroup 1 name : un-intervened endometrial cancer
Subgroup 1 number: 36
Subgroup 2 name: healthy controls
Subgroup 2 number: 36
Cohort statistics: Mean (SD);Range
Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
---|---|---|---|---|---|---|---|---|
72 | un-intervened endometrial cancer | 36 | healthy | 36 |
Sample information
Description: MiRNA 27a was significantly associated with type I endometroid endometrial cancer.
Sample type : serum
Sample method: RT-qPCR
Expression pattern : circulating overexpression cut off= 0.2872
Expression elevation: Relative quantifcation miRNA expression in patients ΔΔCt: is the diference of ΔCt value between the cases and the average of control (ΔΔCt=ΔCt cases – average ΔCt control). The relative quantifcation of miRNA expression was presented as the fold change normalized to the spike in reference mirna 39 and relative to the healthy control samples. Relative quantifcation miRNA expression in healthy control=2–ΔΔCt ΔCt = Ct (target miRNA) − Ct (reference miRNA) ΔΔCt = ΔCt of control − average ΔCt of control
Disease information
Subgroup 1 age: 57.6 ± 8.3
Subgroup 2 age: 53.7±9.4
Related information
HGNC miRNA approved symbol: MIR27A
HGNC miRNA approved name: microRNA 27a
HGNC miRNA locus type: RNA, micro
HGNC miRNA symbol status: Approved
HGNC miRNA ID: HGNC:31613
HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31613
Stem loop sequence symbol: hsa-mir-27a
Stem loop sequence accession: MI0000085
Stem loop sequence gene family: MIPF0000036
Stem loop sequence annotation confidence: high
Mature sequence symbol: hsa-miR-27a-5p $hsa-miR-27a-3p
Mature sequence accession: MIMAT0004501$ MIMAT0000084
Previous IDs: hsa-miR-27a*$ hsa-miR-27a
Evidence: experimental; cloned[PMID:17604727]$ experimental; cloned [PMID:11679670,PMID:15325244,PMID:17604727,PMID:17616659], Northern [PMID:11679670]
miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000085