Basic information
Biomarker: AL161431.1
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Shandong
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
Sample information
Description: Our novel results indicate that AL161431.1 targets and binds to miR-1252-5p, resulting in the de-repression of MAPK signaling in EC cells. This highlights the potential for AL161431.1 to be targeted as a potent therapeutic strategy in the treatment of EC.
Expression pattern : high expression
Validation in cell line : cell lines(HEC1-B, KLE, HEC1-A)
Validation in cell method : qRT-PCR, Western blot ,. Cell migration , wound healing,colony formation assays
Validation involved pathway : MAPK Signaling
Disease information
Related information
Funtion description: High expression levels of AL161431.1 were observed in EC patients, tissues, and cells. Loss-of-function experiments validated the carcinogenic role of AL161431.1. Based on the determined cytoplasmic location of AL161431.1, we investigated the ceRNA network and its relation to AL161431.1, miR-1252-5p, and MAPK (mitogen-activated protein kinase) signaling in EC.
