Basic information

Biomarker: AL161431.1

Histology type: endometrial carcinoma

Cohort characteristics

Country: China

Region: Shandong

Followed up time :

Total number Group I Group I number Group II Group II number Group III Group III number Group IV Group IV number

Sample information

Description: Our novel results indicate that AL161431.1 targets and binds to miR-1252-5p, resulting in the de-repression of MAPK signaling in EC cells. This highlights the potential for AL161431.1 to be targeted as a potent therapeutic strategy in the treatment of EC.

Expression pattern : high expression

Validation in cell line : cell lines(HEC1-B, KLE, HEC1-A)

Validation in cell method : qRT-PCR, Western blot ,. Cell migration , wound healing,colony formation assays

Validation involved pathway : MAPK Signaling

Disease information

Related information

Funtion description: High expression levels of AL161431.1 were observed in EC patients, tissues, and cells. Loss-of-function experiments validated the carcinogenic role of AL161431.1. Based on the determined cytoplasmic location of AL161431.1, we investigated the ceRNA network and its relation to AL161431.1, miR-1252-5p, and MAPK (mitogen-activated protein kinase) signaling in EC.

Visulization