Basic information
Biomarker: microRNA-145
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Hebei
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 33 | G1EC | 11 | grade 3 endometrial carcinoma | 6 | human endometrium | 6 |
Sample information
Description: Our results strongly suggested that miR-145 is a tumor cell differentiation-inducing agent in endometrial carcinoma, and that miR-145 or OCT4 may be useful markers for grading endometrial carcinoma.
Sample type : tissue
Sample method: TaqMan microRNA assays/real-time PCR
Expression pattern : up-regulation
Validation in cell line : Ishikawa cell line
Validation in cell method : Quantitative Real-Time PCR,Flow Cytometric Analysis,Western Blot Analysis,
Validation in animal model : Male athymic nude mice (4-6 weeks of age)
Disease information
Related information
HGNC miRNA approved symbol: MIR27A
HGNC miRNA approved name: microRNA 27a
HGNC miRNA locus type: RNA, micro
HGNC miRNA symbol status: Approved
HGNC miRNA ID: HGNC:31613
HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31613
Stem loop sequence symbol: hsa-mir-27a
Stem loop sequence accession: MI0000085
Stem loop sequence gene family: MIPF0000036
Stem loop sequence annotation confidence: high
Mature sequence symbol: hsa-miR-27a-5p $hsa-miR-27a-3p
Mature sequence accession: MIMAT0004501$ MIMAT0000084
Previous IDs: hsa-miR-27a*$ hsa-miR-27a
Evidence: experimental; cloned[PMID:17604727]$ experimental; cloned [PMID:11679670,PMID:15325244,PMID:17604727,PMID:17616659], Northern [PMID:11679670]
miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000085
