Basic information

Biomarker: miR-125b

Histology type: endometrioid endometrial carcinoma

Cohort characteristics

Country: China

Region: Shenyang

Study type: retrospective study

Followed up time :

Cohort statistics: Range

Total number Group I Group I number Group II Group II number Group III Group III number Group IV Group IV number
80 EEC 50 NE 30

Sample information

Description: Aberrantly expressed miR-125b contributes to HEC1B cells invasion partly through directly down-regulating ERBB2 protein expression in EEC. This miRNA signature offers a novel potential therapeutic strategy for EEC.

Sample type : tissue

Sample method: real-time quantitative PCR

Expression pattern : aberrantly expressed

Validation in cell line : The human EEC cell line HEC1B

Validation in cell method : Transfection,Invasion assays,Vector construction and Luciferase reporter assay,Western blotting,

Validation involved pathway : ERBB2

Disease information

Cohort age: 46-59

Related information

HGNC miRNA approved symbol: MIR27A

HGNC miRNA approved name: microRNA 27a

HGNC miRNA locus type: RNA, micro

HGNC miRNA symbol status: Approved

HGNC miRNA ID: HGNC:31613

HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31613

Stem loop sequence symbol: hsa-mir-27a

Stem loop sequence accession: MI0000085

Stem loop sequence gene family: MIPF0000036

Stem loop sequence annotation confidence: high

Mature sequence symbol: hsa-miR-27a-5p $hsa-miR-27a-3p

Mature sequence accession: MIMAT0004501$ MIMAT0000084

Previous IDs: hsa-miR-27a*$ hsa-miR-27a

Evidence: experimental; cloned[PMID:17604727]$ experimental; cloned [PMID:11679670,PMID:15325244,PMID:17604727,PMID:17616659], Northern [PMID:11679670]

miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000085

Visulization