Basic information
Biomarker: miR-125b
Histology type: endometrioid endometrial carcinoma
Cohort characteristics
Country: China
Region: Shenyang
Study type: retrospective study
Followed up time :
Cohort statistics: Range
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 80 | EEC | 50 | NE | 30 |
Sample information
Description: Aberrantly expressed miR-125b contributes to HEC1B cells invasion partly through directly down-regulating ERBB2 protein expression in EEC. This miRNA signature offers a novel potential therapeutic strategy for EEC.
Sample type : tissue
Sample method: real-time quantitative PCR
Expression pattern : aberrantly expressed
Validation in cell line : The human EEC cell line HEC1B
Validation in cell method : Transfection,Invasion assays,Vector construction and Luciferase reporter assay,Western blotting,
Validation involved pathway : ERBB2
Disease information
Cohort age: 46-59
Related information
HGNC miRNA approved symbol: MIR27A
HGNC miRNA approved name: microRNA 27a
HGNC miRNA locus type: RNA, micro
HGNC miRNA symbol status: Approved
HGNC miRNA ID: HGNC:31613
HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31613
Stem loop sequence symbol: hsa-mir-27a
Stem loop sequence accession: MI0000085
Stem loop sequence gene family: MIPF0000036
Stem loop sequence annotation confidence: high
Mature sequence symbol: hsa-miR-27a-5p $hsa-miR-27a-3p
Mature sequence accession: MIMAT0004501$ MIMAT0000084
Previous IDs: hsa-miR-27a*$ hsa-miR-27a
Evidence: experimental; cloned[PMID:17604727]$ experimental; cloned [PMID:11679670,PMID:15325244,PMID:17604727,PMID:17616659], Northern [PMID:11679670]
miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000085
