Basic information

Biomarker: miR-203

Histology type: endometrioid endometrial carcinoma

Cohort characteristics

Country: USA

Region: St. Louis

Followed up time :

Total number Group I Group I number Group II Group II number Group III Group III number Group IV Group IV number
252 EEC 171 NEEC 37 ovarian cancer/cervix 24;10 normal endometrium 10

Sample information

Description: Hypermethylation of miR-203 is a frequent event in endometrial carcinomas and is strongly associated with microsatellite instability and MLH1 methylation status. Thus, miR-203 methylation level might represent a marker for patients with endometrioid .

Sample type : tissue

Sample method: COBRA/RT-qPCR

Expression pattern : hypermethylation

Validation involved pathway : SOX4 is targeted by miR-203

Validation in animal model : Human endometrial cancer cell lines, AN3CA, HEC1A, Ishikawa, KLE, RL95-2 and SK-UT-1B, and a normal endometrial cell line, E6/E7

Disease information

Related information

Expression figure legend: Hypermethylation of miR-203 in subtypes of primary gynecological tumors

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015135/figure/F4/

HGNC miRNA approved symbol: MIR203A

HGNC miRNA approved name: microRNA 203a

HGNC miRNA locus type: RNA, micro

HGNC miRNA symbol status: Approved

HGNC miRNA ID: HGNC:31581

HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31581

Stem loop sequence symbol: hsa-mir-203a

Stem loop sequence accession: MI0000283

Stem loop sequence gene family: MIPF0000108

Stem loop sequence annotation confidence: high

Mature sequence symbol: hsa-miR-203a-5p $ hsa-miR-203a-3p

Mature sequence accession: MIMAT0031890$MIMAT0000264

Previous IDs: $hsa-miR-203a$

Evidence: not experimental $experimental; cloned [PMID:17604727]

miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000283

Visulization