Basic information
Biomarker: miR-203
Histology type: endometrioid endometrial carcinoma
Cohort characteristics
Country: USA
Region: St. Louis
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 252 | EEC | 171 | NEEC | 37 | ovarian cancer/cervix | 24;10 | normal endometrium | 10 |
Sample information
Description: Hypermethylation of miR-203 is a frequent event in endometrial carcinomas and is strongly associated with microsatellite instability and MLH1 methylation status. Thus, miR-203 methylation level might represent a marker for patients with endometrioid .
Sample type : tissue
Sample method: COBRA/RT-qPCR
Expression pattern : hypermethylation
Validation involved pathway : SOX4 is targeted by miR-203
Validation in animal model : Human endometrial cancer cell lines, AN3CA, HEC1A, Ishikawa, KLE, RL95-2 and SK-UT-1B, and a normal endometrial cell line, E6/E7
Disease information
Related information
Expression figure legend: Hypermethylation of miR-203 in subtypes of primary gynecological tumors
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015135/figure/F4/
HGNC miRNA approved symbol: MIR203A
HGNC miRNA approved name: microRNA 203a
HGNC miRNA locus type: RNA, micro
HGNC miRNA symbol status: Approved
HGNC miRNA ID: HGNC:31581
HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31581
Stem loop sequence symbol: hsa-mir-203a
Stem loop sequence accession: MI0000283
Stem loop sequence gene family: MIPF0000108
Stem loop sequence annotation confidence: high
Mature sequence symbol: hsa-miR-203a-5p $ hsa-miR-203a-3p
Mature sequence accession: MIMAT0031890$MIMAT0000264
Previous IDs: $hsa-miR-203a$
Evidence: not experimental $experimental; cloned [PMID:17604727]
miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000283
