Basic information

Biomarker: ABHD11-AS1

Histology type: endometrial carcinoma

Cohort characteristics

Country: China

Region: Guangzhou

Followed up time :

Subgroup 1 name : EC

Subgroup 1 number: 89

Subgroup 2 name: normal endometrial tissue

Subgroup 2 number: 27

Cohort statistics: cutoff<55;cutoff>55

Total number Group I Group I number Group II Group II number Group III Group III number Group IV Group IV number
116 EC 89 normal endometrial tissue 27

Sample information

Description: In conclusion, this study reveals ABHD11‐AS1 is up‐regulated and promotes tumorigenesis in endometrial carcinoma by positively targeting cyclin D1. This is the first demonstration of an oncogenic role for ABHD11‐AS1 in endometrial carcinoma; this finding could potentially pave the way for the development of novel strategies for diagnosis and treatment.

Sample type : tissue

Sample method: qPCR/Western blotting

Expression pattern : overexpression

Validation in cell line : cell lines (HEC-1B)

Validation in cell method : Cell proliferation assays, Cell cycle assays,Apoptosis assays,Wound‐healing assay,Cell invasion assays,Real‐time PCR,Western blotting,RNA pull‐down assays,

Validation in animal model : 4‐week‐old nude mice

Disease information

Cohort age: 38;51

Related information

Funtion description: ABHD11-AS1 was significantly overexpressed in endometrial carcinoma. Overexpression of lncRNA ABHD11-AS1 promoted the proliferation, G1-S progression, invasion and migration of endometrial cancer cells; inhibited apoptosis; up-regulated cyclin D1, CDK1, CDK2, CDK4, Bcl-xl and VEGFA; and down-regulated p16, while ABHD11-AS1 down-regulation has the opposite effect. Overexpression of lncRNA ABHD11-AS1 increased the tumorigenicity and up-regulated cyclin D1 in an in vivo model of endometrial cancer in nude mice. LncRNA ABHD11-AS1 functions as an oncogene to promote cell proliferation and invasion in endometrial carcinoma by positively targeting cyclin D1.

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