Basic information
Biomarker: ABHD11-AS1
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Guangzhou
Followed up time :
Subgroup 1 name : EC
Subgroup 1 number: 89
Subgroup 2 name: normal endometrial tissue
Subgroup 2 number: 27
Cohort statistics: cutoff<55;cutoff>55
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 116 | EC | 89 | normal endometrial tissue | 27 |
Sample information
Description: In conclusion, this study reveals ABHD11‐AS1 is up‐regulated and promotes tumorigenesis in endometrial carcinoma by positively targeting cyclin D1. This is the first demonstration of an oncogenic role for ABHD11‐AS1 in endometrial carcinoma; this finding could potentially pave the way for the development of novel strategies for diagnosis and treatment.
Sample type : tissue
Sample method: qPCR/Western blotting
Expression pattern : overexpression
Validation in cell line : cell lines (HEC-1B)
Validation in cell method : Cell proliferation assays, Cell cycle assays,Apoptosis assays,Wound‐healing assay,Cell invasion assays,Real‐time PCR,Western blotting,RNA pull‐down assays,
Validation in animal model : 4‐week‐old nude mice
Disease information
Cohort age: 38;51
Related information
Funtion description: ABHD11-AS1 was significantly overexpressed in endometrial carcinoma. Overexpression of lncRNA ABHD11-AS1 promoted the proliferation, G1-S progression, invasion and migration of endometrial cancer cells; inhibited apoptosis; up-regulated cyclin D1, CDK1, CDK2, CDK4, Bcl-xl and VEGFA; and down-regulated p16, while ABHD11-AS1 down-regulation has the opposite effect. Overexpression of lncRNA ABHD11-AS1 increased the tumorigenicity and up-regulated cyclin D1 in an in vivo model of endometrial cancer in nude mice. LncRNA ABHD11-AS1 functions as an oncogene to promote cell proliferation and invasion in endometrial carcinoma by positively targeting cyclin D1.
