Basic information
Biomarker: miR-34a
Histology type: endometrial carcinoma
Stage: high risk
Cohort characteristics
Study type: surgically treated
Followed up time :
Subgroup 1 name : No recurrence
Subgroup 1 number: 57
Subgroup 2 name: Recurrence
Subgroup 2 number: 56
Cohort statistics: cutoff<675;cutoff>67
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 113 | recurrent | 57 | non-recurrent | 56 |
Sample information
Description: Our results demonstrate the expression of L1CAM and miR-34a in EC as prognostic factors that identify subgroup of patients at high risk of recurrence suggesting for them more aggressive schedules of treatment.
Sample type : tissue
Sample method: Reverse transcription and qRT-PCR amplification
Expression pattern : low miR-34a
Disease information
Cohort age: 61;52
Subgroup 1 age: 34;22
Subgroup 2 age: 27;30
Related information
Expression figure legend: In the Box Plot are reported the miR-34a values in the two subgroups of patients (mRNA L/L1CAM H and mRNA H/L1CAM L)
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035393/figure/Fig6/
HGNC miRNA approved symbol: MIR34A
HGNC miRNA approved name: microRNA 34a
HGNC miRNA locus type: RNA, micro
HGNC miRNA symbol status: Approved
HGNC miRNA ID: HGNC:31635
HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31635
Stem loop sequence symbol: hsa-mir-34a
Stem loop sequence accession: MI0000268
Stem loop sequence gene family: MIPF0000039
Stem loop sequence annotation confidence: high
Mature sequence symbol: hsa-miR-34a-5p $hsa-miR-34a-3p
Mature sequence accession: MIMAT0000255$MIMAT0004557
Previous IDs: hsa-miR-34a$hsa-miR-34a*
Evidence: experimental; cloned [PMID:12554860,PMID:17604727,PMID:17616659]$experimental; cloned [PMID:17604727]
miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268
