Basic information

Biomarker: miR-34a

Histology type: endometrial carcinoma

Stage: high risk

Cohort characteristics

Study type: surgically treated

Followed up time :

Subgroup 1 name : No recurrence

Subgroup 1 number: 57

Subgroup 2 name: Recurrence

Subgroup 2 number: 56

Cohort statistics: cutoff<675;cutoff>67

Total number Group I Group I number Group II Group II number Group III Group III number Group IV Group IV number
113 recurrent 57 non-recurrent 56

Sample information

Description: Our results demonstrate the expression of L1CAM and miR-34a in EC as prognostic factors that identify subgroup of patients at high risk of recurrence suggesting for them more aggressive schedules of treatment.

Sample type : tissue

Sample method: Reverse transcription and qRT-PCR amplification

Expression pattern : low miR-34a

Disease information

Cohort age: 61;52

Subgroup 1 age: 34;22

Subgroup 2 age: 27;30

Related information

Expression figure legend: In the Box Plot are reported the miR-34a values in the two subgroups of patients (mRNA L/L1CAM H and mRNA H/L1CAM L)

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035393/figure/Fig6/

HGNC miRNA approved symbol: MIR34A

HGNC miRNA approved name: microRNA 34a

HGNC miRNA locus type: RNA, micro

HGNC miRNA symbol status: Approved

HGNC miRNA ID: HGNC:31635

HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31635

Stem loop sequence symbol: hsa-mir-34a

Stem loop sequence accession: MI0000268

Stem loop sequence gene family: MIPF0000039

Stem loop sequence annotation confidence: high

Mature sequence symbol: hsa-miR-34a-5p $hsa-miR-34a-3p

Mature sequence accession: MIMAT0000255$MIMAT0004557

Previous IDs: hsa-miR-34a$hsa-miR-34a*

Evidence: experimental; cloned [PMID:12554860,PMID:17604727,PMID:17616659]$experimental; cloned [PMID:17604727]

miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000268

Visulization