Basic information
Biomarker: miR-142
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Qingdao
Followed up time :
Subgroup 1 name : low level
Subgroup 2 name: high low
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 49 | EC | 49 |
Sample information
Description: Low-level miR-142 was closely linked with the poor prognosis of EC patients； miR-142 restricted EC proliferation by targeting CCND1.
Sample type : tissue
Sample method: immunohistochemistry,quantitative real-time PCR
Expression pattern : low-level
Validation in cell line : Ishikawa (ISK) and HEC-1A cells
Validation in cell method : MTT assay,Colony formation assay,Western blot,Quantitative real-time PCR,
Validation involved pathway : Cyclin D1
Validation in animal model : Six-weekold male athymic nude mice
Disease information
Related information
HGNC miRNA approved symbol: MIR142
HGNC miRNA approved name: microRNA 142
HGNC miRNA locus type: RNA, micro
HGNC miRNA symbol status: Approved
HGNC miRNA ID: HGNC:31529
HGNC miRNA link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:31529
Stem loop sequence symbol: hsa-mir-142
Stem loop sequence accession: MI0000458
Stem loop sequence gene family: MIPF0000084
Stem loop sequence annotation confidence: high
Mature sequence symbol: hsa-miR-142-5p$hsa-miR-142-3p
Mature sequence accession: MIMAT0000433 $MIMAT0000434
Evidence: experimental; cloned [PMID:15325244,PMID:17604727]$experimental; cloned [PMID:14573789,PMID:15325244, PMID:17604727]
miRBase link: https://www.mirbase.org/cgi-bin/mirna_entry.pl?acc=MI0000458
