Basic information
Biomarker: hsa_circ_0002577
Histology type: endometrial carcinoma
Stage: advanced stage
Cohort characteristics
Country: China
Region: Shengjing
Followed up time :
Subgroup 1 name : EC tissues
Subgroup 1 number: 84
Subgroup 2 name: adjacent normal tissues
Subgroup 2 number: 84
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 168 | EC tissues | 84 | adjacent normal tissues | 84 |
Sample information
Description: Our study showed that circRNA hsa_circ_002577 accelerated EC progression by acting as a miR-625-5p sponge, upregulating IGF1R and activating the PI3K/Akt pathway, suggesting the potential therapeutic use of hsa_circ_002577 in EC treatment.
Sample type : tissue
Sample method: FISH
Expression pattern : higher expression(≥ median)
Validation in cell line : cell lines(HEC-1-B, AN3-CA, KLE, HEC1-A, and Ishikawa;hEEC)
Validation in cell method : qRT-PCR,RNA immunoprecipitation (RIP) assay,Western blot
Validation involved pathway : IGF1R/PI3K/Akt pathway
Validation in animal model : Female BALB/c nude mice
Disease information
Related information
Expression figure legend: The expression level of hsa_circ_0002577 in EC tissues and cell lines and its clinical significance
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450704/figure/Fig1/
Survival figure legend: The Kaplan-Meier survival analysis of EC patients with high (n = 42) and low (n = 42) expressions of low hsa_circ_0002577.
Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450704/figure/Fig1/
miRBase link: hsa_circ_0002577
CircRNA_ID chr1:224599128-224607317
