Basic information

Biomarker: hsa_circ_0002577

Histology type: endometrial carcinoma

Stage: advanced stage

Cohort characteristics

Country: China

Region: Shengjing

Followed up time :

Subgroup 1 name : EC tissues

Subgroup 1 number: 84

Subgroup 2 name: adjacent normal tissues

Subgroup 2 number: 84

Total number Group I Group I number Group II Group II number Group III Group III number Group IV Group IV number
168 EC tissues 84 adjacent normal tissues 84

Sample information

Description: Our study showed that circRNA hsa_circ_002577 accelerated EC progression by acting as a miR-625-5p sponge, upregulating IGF1R and activating the PI3K/Akt pathway, suggesting the potential therapeutic use of hsa_circ_002577 in EC treatment.

Sample type : tissue

Sample method: FISH

Expression pattern : higher expression(≥ median)

Validation in cell line : cell lines(HEC-1-B, AN3-CA, KLE, HEC1-A, and Ishikawa;hEEC)

Validation in cell method : qRT-PCR,RNA immunoprecipitation (RIP) assay,Western blot

Validation involved pathway : IGF1R/PI3K/Akt pathway

Validation in animal model : Female BALB/c nude mice

Disease information

Related information

Expression figure legend: The expression level of hsa_circ_0002577 in EC tissues and cell lines and its clinical significance

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450704/figure/Fig1/

Survival figure legend: The Kaplan-Meier survival analysis of EC patients with high (n = 42) and low (n = 42) expressions of low hsa_circ_0002577.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7450704/figure/Fig1/

miRBase link: hsa_circ_0002577

CircRNA_ID chr1:224599128-224607317

Visulization