Basic information
Biomarker: LINC01133
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Tianjin
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
Sample information
Description: We demonstrated that LINC01133 expression are associated with EC development and progression. Our findings suggest a potential role for these lncRNAs as novel EC biomarkers.
Expression pattern : expression
Validation in cell line : Ishikawa (estrogen receptor α-positive) and HEC-1-A (estrogen receptor α-negative) human EC cell lines
Validation in cell method : RT-qPCR,Cell proliferation assay (CCK-8 assay),Flow cytometry analysis of cell cycle distribution,Annexin V-FITC/PI double staining and flow cytometry,Transwell invasion assay,Scratch migration assay,
Disease information
Related information
Funtion description: Through siRNA knockdown of these two lncRNAs, the auther observed decreased viability, cell cycle arrest, and increased apoptosis in two EC cell lines. Using the Transwell and scratch assays, the auther found decreased migration and invasiveness, respectively, of the two EC cell lines.
