Biomarker: TROP2

Histology type: endometrioid endometrial carcinoma

Stage: more aggressive tumors

Country: Turkey

Region: Muğla

Study type: retrospective study

Followed up time :

Subgroup 1 name : score<1

Subgroup 1 number: 30

Subgroup 2 name: score>1

Subgroup 2 number: 33

Conclusion: Overexpression of TROP2 in endometrioid-type endometrial carcinoma seems to be a poor prognostic factor; it may be useful in determining the biologically more aggressive tumors before the treatment

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : overexpression(score>1)

Expression elevation: The presence of membranous staining was evaluated and the percentage of positive cells were scored as 0 (0%), 1 (1–10%), 2 (11–50%), and 3 (51-100%).

Funtion Uniprot: May function as a growth factor receptor.

UniProt ID: P09758

UniProt Link: https://www.uniprot.org/uniprotkb/P09758/entry

Biological function from UniProt: #Sensory transduction #Vision

Molecular function from UniProt:

Tissue specificity from UniProt: Placenta, pancreatic carcinoma cell lines.

Subcellular UniProt: #Amyloid #Membrane

Alternative name from UniProt:

Recommended name: Tumor-associated calcium signal transducer 2

Gene name from HGNC: TACSTD2 (EGP-1, GA733-1, M1S1, TROP2)

HPA class: Disease related genes FDA approved drug targets Human disease related genes

AlphaFold DB: P09758

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P09758

HPA link: https://www.proteinatlas.org/ENSG00000184292-TACSTD2

Tissue specificity RNA from HPA: Tissue enhanced (esophagus, salivary gland, skin)

Tissue expression from HPA: Abundant cytoplasmic and membranous expression in respiratory and squamous epithelial cells.

Single cell type specificity Cell type enhanced (Urothelial cells, Basal prostatic cells, Prostatic glandular cells, Basal respiratory cells, Squamous epithelial cells, Club cells)

Immune cell specificity: Immune cell enhanced (eosinophil)

Subcellular summary HPA Located in Nucleoli, Vesicles, Plasma membrane (Single cell variability)

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000184292-TACSTD2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000184292-TACSTD2/pathology/endometrial+cancer

Phenotype ID: 204870

Disease: Corneal dystrophy, gelatinous drop-like (GDLD)

Note1: The disease is caused by variants affecting the gene represented in this entry

Note2: CDGDL AMYLOIDOSIS, CORNEAL AMYLOID CORNEAL DYSTROPHY, JAPANESE TYPE CORNEAL DYSTROPHY, LATTICE TYPE III LATTICE CORNEAL DYSTROPHY, TYPE III

OMIM: 137290;204870;

OMIM link1: https://www.omim.org/entry/204870

OMIM link2: https://www.omim.org/entry/137290;https://www.omim.org/entry/204870

Phenotype: CORNEAL DYSTROPHY, GELATINOUS DROP-LIKE; GDLD

HGNC ID: HGNC:11530

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11530