Biomarker: VDAC2

Histology type: endometrial carcinoma

Country: Poland

Region: Lodz

Followed up time :

Subgroup 1 name : EC

Subgroup 1 number: 116

Subgroup 2 name: control

Subgroup 2 number: 41

Conclusion: Our results suggest that increased expression of voltage-dependent anion channels correlates with tumor progression and may serve as a potential prognostic biomarker in endometrial cancer.

Sample type : tissue

Sample method: Western blotting

Expression pattern : expression(≥ median value)

Statictics: Mean (SD)

Subgroup 1 age: 63.37±11.64

Subgroup 2 age: 59.55±10.17

Funtion Uniprot: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity). The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity). The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432).

UniProt ID: HGNC:12672

UniProt Link: https://www.uniprot.org/uniprotkb/P45880/entry

Biological function from UniProt: #Ion transport #Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in all tissues examined (PubMed:8420959).

Subcellular UniProt: #Membrane #Mitochondrion #Mitochondrion outer membrane

Alternative name from UniProt:

Recommended name: Voltage-dependent anion-selective channel protein 2

Gene name from HGNC: VDAC2

HPA class: Located in Mitochondria

AlphaFold DB: P45880

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P45880

HPA link: https://www.proteinatlas.org/ENSG00000165637-VDAC2

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Ubiquitous cytoplasmic expression with a granular pattern.

Single cell type specificity Low cell type specificity

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Mitochondria

Cancer prognostic summary HPA Prognostic marker in head and neck cancer (unfavorable) and liver cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000165637-VDAC2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000165637-VDAC2/pathology/endometrial+cancer

OMIM: 193245

OMIM link2: https://www.omim.org/entry/193245

HGNC ID: HGNC:12672

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12672