Biomarker: vimentin

Histology type: endometrial carcinoma

Country: China

Region: Beijing

Followed up time :

Subgroup 1 name : Vimentin negative

Subgroup 1 number: 64

Subgroup 2 name: Vimentin positive

Subgroup 2 number: 287

Conclusion: Negative vimentin expression correlates with tumor metastasis and worse overall survival in EC, suggesting that it may be an excellent prognostic biomarker for this disease. The mechanism by which vimentin contributes to EC progression needs to be explored in the future.

Sample type : tissue

Sample method: immunohistochemistry

Funtion Uniprot: Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.By Similarity Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2.

Biological function from UniProt: #Host-virus interaction

Molecular function from UniProt:

Tissue specificity from UniProt: Highly expressed in fibroblasts, some expression in T- and B-lymphocytes, and little or no expression in Burkitt's lymphoma cell lines. Expressed in many hormone-independent mammary carcinoma cell lines

Subcellular UniProt: Localized to the Intermediate filaments

Caution: Was reported to interact with SLC6A4, however the paper was retracted as some results and conclusions are not reliable.

Recommended name: Vimentin

Gene name from HGNC: VIM

HPA class: Disease related genes Human disease related genes Plasma proteins

AlphaFold DB: P08670

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P08670

Induction: Up-regulated by muramyl-dipeptide and lipopolysaccharide.

Tissue specificity RNA from HPA: Low tissue specificity

Single cell type specificity Cell type enhanced (Schwann cells, granulocytes, Muller glia cells, Ovarian stromal cells)

Immune cell specificity: Low immune cell specificity

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable) and endometrial cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000026025-VIM/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000026025-VIM/pathology/endometrial+cancer

OMIM: 193060

OMIM link2: https://www.omim.org/entry/193060

HGNC ID: HGNC:12692

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12692