Biomarker: S100A7

Histology type: endometrial clear cell carcinoma

Country: UK

Study type: prospective case-control study

Followed up time :

Conclusion: A patient-friendly, urine-based test could offer a non-invasive endometrial cancer detection tool in symptomatic women. Validation in a larger independent cohort is warranted.

Sample type : urine

Sample method: mass spectrometric analysis

UniProt ID: P31151

UniProt Link: https://www.uniprot.org/uniprotkb/P31151/external-links

Molecular function from UniProt:

Tissue specificity from UniProt: Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients.

Subcellular UniProt: #Cytoplasm #Secreted

Alternative name from UniProt:

Recommended name: Protein S100-A7

Gene name from HGNC: S100A7

HPA class: Cancer-related genes Plasma proteins

AlphaFold DB: P31151

AlphaFold Link: https://www.uniprot.org/uniprotkb/P31151/entry

HPA link: https://www.proteinatlas.org/ENSG00000143556-S100A7

Tissue specificity RNA from HPA: Group enriched (esophagus, lymphoid tissue, skin, vagina)

Tissue expression from HPA: Squamous epithelium - Innate immune response (mainly)

Single cell type specificity Squamous epithelial cells - Keratinization (mainly)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000143556-S100A7/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000143556-S100A7/pathology/endometrial+cancer

OMIM: 600353

OMIM link2: https://www.omim.org/entry/600353

HGNC ID: HGNC:10497

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10497