Basic information
Biomarker: ECM1
Histology type: endometrial clear cell carcinoma
Cohort characteristics
Country: UK
Study type: prospective case-control study
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 100 | EC | 50 | controls | 50 |
Sample information
Conclusion: A patient-friendly, urine-based test could offer a non-invasive endometrial cancer detection tool in symptomatic women. Validation in a larger independent cohort is warranted.
Sample type : urine
Sample method: mass spectrometric analysis
Disease information
Related information
Funtion Uniprot: Involved in endochondral bone formation as negative regulator of bone mineralization. Stimulates the proliferation of endothelial cells and promotes angiogenesis. Inhibits MMP9 proteolytic activity
UniProt ID: Q16610
UniProt Link: https://www.uniprot.org/uniprotkb/Q16610
Biological function from UniProt: #Angiogenesis #Biomineralization #Mineral balance #Osteogenesis
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed in breast cancer tissues. Little or no expression observed in normal breast tissues. Expressed in skin; wide expression is observed throughout the dermis with minimal expression in the epidermis.
Subcellular UniProt: #Extracellular matrix #Secreted
Alternative name from UniProt:
Recommended name: Extracellular matrix protein 1
Gene name from HGNC: ECM1
HPA class: Disease related genes Human disease related genes Plasma proteins
AlphaFold DB: Q16610
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q16610
HPA link: https://www.proteinatlas.org/ENSG00000143369-ECM1
Tissue specificity RNA from HPA: Tissue enhanced (epididymis, esophagus)
Tissue expression from HPA: Squamous epithelium - Keratinization (mainly)
Single cell type specificity Cell type enhanced (Suprabasal keratinocytes, Fibroblasts, Endometrial stromal cells, Melanocytes)
Immune cell specificity: Not detected in immune cells
Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), urothelial cancer (unfavorable) and pancreatic cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000143369-ECM1/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000143369-ECM1/pathology/endometrial+cancer
OMIM: 602201
OMIM link2: https://www.omim.org/entry/602201
HGNC ID: HGNC:3153
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3153
