Biomarker: C1RL

Histology type: endometrial clear cell carcinoma

Country: UK

Study type: prospective case-control study

Followed up time :

Conclusion: A patient-friendly, urine-based test could offer a non-invasive endometrial cancer detection tool in symptomatic women. Validation in a larger independent cohort is warranted.

Sample type : urine

Sample method: mass spectrometric analysis

Funtion Uniprot: Mediates the proteolytic cleavage of HP/haptoglobin in the endoplasmic reticulum.

UniProt ID: Q9NZP8

UniProt Link: https://www.uniprot.org/uniprotkb/Q9NZP8/entry

Biological function from UniProt: #Complement pathway #Immunity #Innate immunity

Molecular function from UniProt:

Tissue specificity from UniProt: Highly expressed in placenta, liver, kidney, pancreas, moderately in lung, spleen, prostate, ovary, colon, and PBL, and weakly in heart, skeletal muscle, thymus, testis, and small intestine. Expressed in PC-3 (prostate adenocarcinoma) and SK-OV-3 (ovary adenocarcinoma) cells, but not in LoVo and HT-29 (colon adenocarcinoma), SMMC7721 (hepatocellular carcinoma), CaoV-3 (ovary adenocarcinoma), HeLa (cervix epithelioid carcinoma), MCF-7 (breast adenocarcinoma), U-251MG (glioma) or A-549 (lung carcinoma) cells. Widely expressed in myeloid leukemia cell lines, including K-562 (chronic myelogenous leukemia), THP-1 (myelomonocytic leukemia), HL-60 and NB4 (promyelocytic leukemia), and KG-1 (acute myelogenous leukemia) cells. Expressed mainly in the liver and in serum (at protein level).

Subcellular UniProt: #Secreted

Caution: Does not associate with the C1 complex. According to PubMed:15385675, doesn't cleave the proform of complement C1s.

Recommended name: Complement C1r subcomponent-like protein

Gene name from HGNC: C1RL

HPA class: Enzymes Plasma proteins

AlphaFold DB: Q9NZP8

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9NZP8

Induction: Up-regulated in monocytes and dendritic cells (DC) undergoing maturation or activation.

HPA link: https://www.proteinatlas.org/ENSG00000139178-C1RL

Tissue specificity RNA from HPA: Tissue enhanced (liver)

Tissue expression from HPA: Liver - Metabolism (mainly)

Single cell type specificity Cell type enhanced (Hepatocytes)

Immune cell specificity: Immune cell enhanced (neutrophil)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable) and breast cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000139178-C1RL/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000139178-C1RL/pathology/endometrial+cancer

OMIM: 608974

OMIM link2: https://www.omim.org/entry/608974

HGNC ID: HGNC:21265

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21265