Biomarker: FABP5

Histology type: endometrial clear cell carcinoma

Country: UK

Study type: prospective case-control study

Followed up time :

Conclusion: A patient-friendly, urine-based test could offer a non-invasive endometrial cancer detection tool in symptomatic women. Validation in a larger independent cohort is warranted.

Sample type : urine

Sample method: mass spectrometric analysis

Funtion Uniprot: Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058, PubMed:21395585). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987).

Biological function from UniProt: #Lipid transport #Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Keratinocytes; highly expressed in psoriatic skin (PubMed:8092987). Expressed in brain gray matter (PubMed:21395585)

Subcellular UniProt: #Cytoplasm #Nucleus #Secreted #Synapse

Alternative name from UniProt:

Caution: While mouse FABP5 is found only in the monomeric form, human FABP5 can exist as a monomer as well as a domain-swapped dimer.

Catalytic activity: hexadecanoate(out) = hexadecanoate(in)

Recommended name: Fatty acid-binding protein 5

Gene name from HGNC: FABP5

HPA class: Cancer-related genes Metabolic proteins Plasma proteins Transporters

AlphaFold DB: Q01469

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q01469