Basic information
Biomarker: TXN
Histology type: endometrial clear cell carcinoma
Cohort characteristics
Country: UK
Study type: prospective case-control study
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 100 | EC | 50 | controls | 50 |
Sample information
Conclusion: A patient-friendly, urine-based test could offer a non-invasive endometrial cancer detection tool in symptomatic women. Validation in a larger independent cohort is warranted.
Sample type : urine
Sample method: mass spectrometric analysis
Disease information
Related information
Funtion Uniprot: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:2176490, PubMed:17182577, PubMed:19032234). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity (PubMed:16408020, PubMed:17606900). Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (PubMed:9108029, PubMed:11118054).
Biological function from UniProt: #Electron transport #Transcription #Transcription regulation #Transport
Molecular function from UniProt:
Tissue specificity from UniProt: Up-regulated by ionizing radiation.
Alternative name from UniProt:
Recommended name: Thioredoxin
Gene name from HGNC: TXN
HPA class: Metabolic proteins Plasma proteins
AlphaFold DB: P10599
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P10599
Tissue specificity RNA from HPA: Tissue enhanced (esophagus)
Tissue expression from HPA: Epithelium - Extracellular exosomes (mainly)
Single cell type specificity Cell type enhanced (Suprabasal keratinocytes, Basal respiratory cells, Proximal tubular cells, Squamous epithelial cells)
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA #Cytoplasm #Nucleus #Secreted
Pathology link: https://www.proteinatlas.org/ENSG00000136810-TXN/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000136810-TXN/pathology
