Biomarker: CALML3

Histology type: endometrial clear cell carcinoma

Country: UK

Study type: prospective case-control study

Followed up time :

Conclusion: A patient-friendly, urine-based test could offer a non-invasive endometrial cancer detection tool in symptomatic women. Validation in a larger independent cohort is warranted.

Sample type : urine

Sample method: mass spectrometric analysis

Funtion Uniprot: May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.

UniProt Link: https://www.uniprot.org/uniprotkb/P27482

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in normal mammary, prostate, cervical, and epidermal tissues. It is greatly reduced or undetectable in transformed cells

Alternative name from UniProt:

Miscellaneous: Binds four calcium ions.

Recommended name: Calmodulin-like protein 3

Gene name from HGNC: CALML3

HPA class: Plasma proteins RAS pathway related proteins

AlphaFold DB: P27482

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P27482

Induction: By TGFB1.

HPA link: https://www.proteinatlas.org/ENSG00000178363-CALML3

Tissue specificity RNA from HPA: Tissue enhanced (esophagus, skin, vagina)

Tissue expression from HPA: Squamous epithelium - Keratinization (mainly)

Single cell type specificity Cell type enhanced (Squamous epithelial cells, Suprabasal keratinocytes, Basal keratinocytes, Basal squamous epithelial cells)

Immune cell specificity: Not detected in immune cells

Pathology link: https://www.proteinatlas.org/ENSG00000178363-CALML3/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000178363-CALML3/pathology/endometrial+cancer

OMIM: https://www.omim.org/entry/114184

OMIM link1: 114184

HGNC ID: HGNC:1452

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14524