Biomarker: CRNN

Histology type: endometrial clear cell carcinoma

Country: UK

Study type: prospective case-control study

Followed up time :

Conclusion: A patient-friendly, urine-based test could offer a non-invasive endometrial cancer detection tool in symptomatic women. Validation in a larger independent cohort is warranted.

Sample type : urine

Sample method: mass spectrometric analysis

Funtion Uniprot: Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832). Regulates proliferation induced by pro-inflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832).

UniProt ID: https://www.uniprot.org/uniprotkb/Q9UBG3/external-links

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in the basal skin layer (at protein level) (PubMed:30009832). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular layer), inner root sheath of the hair follicle and in primary keratinocytes (at protein level). Expressed in the squamous epithelium of the cervix, esophagus, foreskin and larynx. Expressed in the fetal bladder and scalp skin. Expressed at very low levels in the lung, kidney, uterus, skeletal muscle, heart and fetal brain. Undetectable or barely detectable in esophageal and oral squamous cell carcinoma compared with the matched adjacent normal esophageal mucosa. Undetectable or barely detectable in larynx and esophagus from patients with pH-documented laryngopharyngeal reflux (LPR)

Recommended name: Cornulin

Gene name from HGNC: CRNN, C1orf10, DRC1, PDRC1, SEP53

HPA class: Disease related genes

AlphaFold DB: Q9UBG3

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9UBG3

Induction: Up-regulated after heat shock, ponasterone A and deoxycholic acid (PubMed:15896671, PubMed:16640557). Induced in response to pro-inflammatory cytokines (PubMed:30009832).

Tissue specificity RNA from HPA: Tissue enhanced (esophagus, vagina)

Tissue expression from HPA: Tissue enhanced (esophagus, vagina)

Single cell type specificity Cell type enriched (Suprabasal keratinocytes)

Subcellular summary HPA #Cytoplasm

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000143536-CRNN/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000169469-SPRR1B/pathology/endometrial+cancer