Basic information
Biomarker: SPRR1B
Histology type: endometrial clear cell carcinoma
Cohort characteristics
Country: UK
Study type: prospective case-control study
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 100 | EC | 50 | controls | 50 |
Sample information
Conclusion: A patient-friendly, urine-based test could offer a non-invasive endometrial cancer detection tool in symptomatic women. Validation in a larger independent cohort is warranted.
Sample type : urine
Sample method: mass spectrometric analysis
Disease information
Related information
Funtion Uniprot: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.
Biological function from UniProt: #Keratinization
Molecular function from UniProt:
Tissue specificity from UniProt: Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea.
Subcellular UniProt: #Cytoplasm
Recommended name: Cornifin-B
Gene name from HGNC: SPRR1B
HPA class: Cancer-related genes
AlphaFold DB: P22528
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P22528
Induction: By carcinogenic agents and by UV light. During squamous differentiation of epidermal keratinocytes.
Developmental stage: Expressed during differentiation of squamous cells.
HPA link: https://www.proteinatlas.org/ENSG00000169469-SPRR1B
Tissue specificity RNA from HPA: Tissue enhanced (cervix, esophagus, vagina)
Tissue expression from HPA: Squamous epithelium - Innate immune response (mainly)
Single cell type specificity Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Serous glandular cells)
Immune cell specificity: Not detected in immune cells
Cancer prognostic summary HPA Prognostic marker in pancreatic cancer (unfavorable), lung cancer (unfavorable) and urothelial cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000169469-SPRR1B/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000169469-SPRR1B/pathology/endometrial+cancer
OMIM link2: 182266
Phenotype: https://www.omim.org/entry/182266
HGNC ID: HGNC:11260
