Biomarker: VDAC1

Histology type: endometrial carcinoma

Country: Poland

Region: Lodz

Followed up time :

Subgroup 1 name : EC

Subgroup 1 number: 116

Subgroup 2 name: control

Subgroup 2 number: 41

Conclusion: Our results suggest that increased expression of voltage-dependent anion channels correlates with tumor progression and may serve as a potential prognostic biomarker in endometrial cancer.

Sample type : tissue

Sample method: Western blotting

Expression pattern : expression(≥ median value)

Statictics: Mean (SD)

Subgroup 1 age: 63.37±11.64

Subgroup 2 age: 59.55±10.17

Funtion Uniprot: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). Binds various signaling molecules, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432). In depolarized mitochondria, acts downstream of PRKN and PINK1 to promote mitophagy or prevent apoptosis; polyubiquitination by PRKN promotes mitophagy, while monoubiquitination by PRKN decreases mitochondrial calcium influx which ultimately inhibits apoptosis (PubMed:32047033). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756). May mediate ATP export from cells (PubMed:30061676)

UniProt ID: P21796

UniProt Link: https://www.uniprot.org/uniprotkb/P21796/entry

Biological function from UniProt: #Apoptosis #Host-virus interaction #Ion transport #Transport

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in erythrocytes (at protein level) (PubMed:27641616). Expressed in heart, liver and skeletal muscle (PubMed:8420959).

Subcellular UniProt: #Cell membrane #Membrane #Mitochondrion #Mitochondrion outer membrane

Alternative name from UniProt:

Activity regulation: Inhibited by nitric oxide.

Recommended name: Voltage-dependent anion-selective channel protein 1

Gene name from HGNC: VDAC1 (MGC111064, PORIN)

HPA class: Plasma proteins

AlphaFold DB: P21796

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P21796

HPA link: https://www.proteinatlas.org/ENSG00000213585-VDAC1

Tissue specificity RNA from HPA: Tissue enhanced (skeletal muscle, tongue)

Tissue expression from HPA: Ubiquitous cytoplasmic expression.

Single cell type specificity Non-specific - Basic cellular processes (mainly)

Immune cell specificity: Low immune cell specificity

Cancer prognostic summary HPA Prognostic marker in lung cancer (unfavorable), head and neck cancer (unfavorable), breast cancer (unfavorable) and liver cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000213585-VDAC1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000213585-VDAC1/pathology/endometrial+cancer

OMIM: 604492

OMIM link2: https://www.omim.org/entry/604492

HGNC ID: HGNC:12669

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12669