Biomarker: KRT15

Histology type: endometrial cancer

Country: China

Region: Handan

Followed up time :

Conclusion: KRT15 is abnormally increased in EC tissue, meanwhile, its upregulation links to the occurrence of lymphovascular invasion, stromal cervical invasion, and poor prognosis in EC patients.

Sample type : tissue

Sample method: immunohistochemistry

Funtion Uniprot: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

UniProt ID: P19012

UniProt Link: https://www.uniprot.org/uniprotkb/P19012

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at protein level). Expressed homogeneously in all cell layers of the esophagus and exocervix, but detected in the basal cell layer only of oral mucosa, skin and in the basal plus the next two layers of the suprabasal epithelium of the palate.

Subcellular UniProt: #Intermediate filament #Keratin

Alternative name from UniProt:

Recommended name: Keratin, type I cytoskeletal 15

Gene name from HGNC: KRT15

HPA class: Cancer-related genes Plasma proteins

AlphaFold DB: P19012

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P19012

HPA link: https://www.proteinatlas.org/ENSG00000171346-KRT15

Tissue specificity RNA from HPA: Group enriched (breast, esophagus, skin, vagina)

Tissue expression from HPA: Squamous epithelium - Keratinization (mainly)

Single cell type specificity Cell type enhanced (Basal squamous epithelial cells, Squamous epithelial cells, Basal keratinocytes, Basal respiratory cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Localized to the Intermediate filaments In addition localized to the Nucleoplasm

Cancer prognostic summary HPA Prognostic marker in breast cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000171346-KRT15/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000171346-KRT15/pathology/endometrial+cancer

Expression figure legend: KRT15 expression was higher in tumor tissue than adjacent tissue.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9302346/figure/F1/

OMIM: 148030

OMIM link2: https://www.omim.org/entry/148030

HGNC ID: HGNC:6421

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6421