Basic information
Biomarker: SOX2
Histology type: (SMARCA4/BRG1)-deficient undifferentiated uterine sarcoma (SDUS),undifferentiated endometrial carcinoma (UDEC) and dedifferentiated endometrial carcinoma (DDEC)
Cohort characteristics
Country: USA
Region: TX
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 10 | SDUS | 2 | hypercalcemic type | 2 | uterine carcinoma with neuroendocrine differentiation | 1 | undifferentiated endometrial carcinoma (UDEC)/dedifferentiated endometrial carcinoma (DDEC) | 5 |
Sample information
Conclusion: All 5 UDEC/DDEC cases showed strong and diffuse nuclear positivity for SOX2, while all SCCOHT and SDUS cases were completely negative. We concluded that SOX2 could be a useful marker for the differential diagnosis between SDUS and UDEC/DDEC.
Sample type : tissues
Sample method: immunohistochemistry
Disease information
Related information
Funtion Uniprot: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Binds to the proximal enhancer region of NANOG (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408). Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity). May function as a switch in neuronal development (By similarity).
UniProt ID: P48431
UniProt Link: https://www.uniprot.org/uniprotkb/P48431
Biological function from UniProt: #Transcription #Transcription regulation
Molecular function from UniProt:
Subcellular UniProt: #Cytoplasm #Nucleus
Recommended name: Transcription factor SOX-2
Gene name from HGNC: SOX2
HPA class: Cancer-related genes Disease related genes Human disease related genes Transcription factors
AlphaFold DB: P48431
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P48431
HPA link: https://www.proteinatlas.org/ENSG00000181449-SOX2
Tissue specificity RNA from HPA: Tissue enhanced (brain, esophagus)
Tissue expression from HPA: Brain - Neuronal signaling (mainly)
Single cell type specificity Cell type enhanced (Muller glia cells, Basal squamous epithelial cells, Squamous epithelial cells, Schwann cells, Club cells)
Immune cell specificity: Not detected in immune cells
Cancer prognostic summary HPA Gene product is not prognostic
Pathology link: https://www.proteinatlas.org/ENSG00000181449-SOX2/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000181449-SOX2/pathology/colorectal+cancer
HGNC ID: HGNC:11195
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11195
