Basic information
Biomarker: Zinc finger E-box binding homeobox 1
Histology type: undifferentiated and de-differentiated endometrial carcinomas (UC/DCs)
Cohort characteristics
Country: Japan
Region: Tochigi
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 242 | UC/DCs | 19 | non-UC/DC endometrial carcinomas | 194 | carcinosarcomas | 29 |
Sample information
Conclusion: Diffuse ZEB1 expression showed high specificity for distinguishing between undifferentiated components and G3ECs; however, ZEB1 expression was not entirely specific to UC/DCs.
Sample type : tissues
Sample method: immunohistochemistry
Expression pattern : upregulated
Disease information
Related information
Funtion Uniprot: Transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters (PubMed:16061479, PubMed:20516212). Represses transcription of E-cadherin (PubMed:16061479). Represses expression of MEOX2 (PubMed:20516212).
UniProt ID: O60315
UniProt Link: https://www.uniprot.org/uniprotkb/O60315
Biological function from UniProt: #Transcription #Transcription regulation
Molecular function from UniProt:
Subcellular UniProt: #Chromosome #Nucleus
Alternative name from UniProt:
Recommended name: Zinc finger E-box-binding homeobox 2
Gene name from HGNC: ZEB2
HPA class: Disease related genes Human disease related genes Transcription factors
AlphaFold DB: O60315
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O60315
Induction: Down-regulated by microRNA-221 (miR-221).
HPA link: https://www.proteinatlas.org/ENSG00000169554-ZEB2
Tissue specificity RNA from HPA: Tissue enhanced (brain)
Tissue expression from HPA: Oligodendrocytes - Myelination (mainly)
Single cell type specificity Cell type enhanced (monocytes, Oligodendrocytes, Inhibitory neurons, NK-cells, Macrophages)
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA Localized to the Nucleoli In addition localized to the Nucleoplasm, Cytosol
Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000169554-ZEB2/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000169554-ZEB2/pathology/endometrial+cancer
OMIM: 605802
OMIM link2: https://www.omim.org/entry/605802
HGNC ID: HGNC:14881
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14881
