Biomarker: ARID1B

Histology type: Dedifferentiated endometrial carcinomas (DDECs)/undifferentiated endometrial carcinomas (UDECs)

Country: Canada

Region: BC

Followed up time :

Conclusion: ARID1B, SMARCA4 and SMARCB1 immunohistochemistry can be used to aid in the differentiation betweenDedifferentiated endometrial carcinomas (DDECs)/undifferentiated endometrial carcinomas (UDECs) andneuroendocrine carcinoma (NEC).

Sample type : tissues

Sample method: immunohistochemistry

Expression pattern : upregulated

Funtion Uniprot: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388)

Biological function from UniProt: #Neurogenesis #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Widely expressed with high levels in heart, skeletal muscle and kidney

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: AT-rich interactive domain-containing protein 1B

Gene name from HGNC: ARID1B

HPA class: Cancer-related genes Disease related genes Human disease related genes Transcription factors

AlphaFold DB: Q8NFD5

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q8NFD5

HPA link: https://www.proteinatlas.org/ENSG00000049618-ARID1B

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Non-specific - Basic cellular processes (mainly)

Single cell type specificity Cell type enhanced (Oligodendrocytes, Inhibitory neurons)

Immune cell specificity: Low immune cell specificity

Pathology link: https://www.proteinatlas.org/ENSG00000049618-ARID1B/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000049618-ARID1B/pathology/endometrial+cancer

OMIM: 614556

OMIM link2: https://www.omim.org/entry/614556