Biomarker: Cyclin D1

Histology type: endometrial cancer

Country: India

Region: Maharashtra

Followed up time :

Conclusion: Cyclin D1 positive staining, p53overexpression and an elevated Ki-67index all had an independent prognostic significance in endometrial cancer.

Sample type : tissues

Sample method: immunohistochemistry

Expression pattern : upregulated

Funtion Uniprot: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162, PubMed:33854235). Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162). Hypophosphorylates RB1 in early G1 phase (PubMed:1833066, PubMed:1827756, PubMed:8114739, PubMed:8302605, PubMed:19412162). Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals (PubMed:1833066, PubMed:1827756, PubMed:8302605, PubMed:19412162). Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity (PubMed:15241418). Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (PubMed:9106657). Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner (PubMed:16569215, PubMed:18417529).

UniProt ID: P24385

UniProt Link: https://www.uniprot.org/uniprotkb/P24385/entry

Biological function from UniProt: Cell cycle, Cell division, DNA damage, Transcription, Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Low tissue specificity

Subcellular UniProt: #Cytoplasm #Membrane #Nucleus

Alternative name from UniProt:

Recommended name: G1/S-specific cyclin-D1

Gene name from HGNC: CCND1 (BCL1, D11S287E, PRAD1, U21B31)

AlphaFold DB: P24385

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P24385

HPA link: https://www.proteinatlas.org/ENSG00000110092-CCND1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic and nuclear expression in several tissues.

Cancer prognostic summary HPA Prognostic marker in pancreatic cancer (unfavorable) and head and neck cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000110092-CCND1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000110092-CCND1/pathology/endometrial+cancer

HGNC ID: HGNC:1582

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1582