Basic information
Biomarker: Pirh2
Histology type: endometrial adenocarcinoma
Cohort characteristics
Country: Egypt
Region: Zagazig
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 120 | EC | 60 | control adjacent tissues | 60 |
Sample information
Conclusion: Mutant p53, high Pirh2, and L1CAM-positive EC are highly aggressive tumors with a shortened survival rate, dismal outcome, and high risk of relapse after the standard protocol of therapy.
Sample type : tissues
Sample method: immunohistochemistry
Expression pattern : upregulated
Disease information
Related information
Funtion Uniprot: E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:19483087, PubMed:19043414, PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:21994467). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (PubMed:19483087, PubMed:19043414). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:21791603). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987).
UniProt ID: Q96PM5
UniProt Link: https://www.uniprot.org/uniprotkb/Q96PM5/
Biological function from UniProt: #Ubl conjugation pathway
Molecular function from UniProt:
Tissue specificity from UniProt: Up-regulated during the S phase of the cell cycle (PubMed:18006823). Expressed at low levels during G phase (PubMed:18006823).
Alternative name from UniProt:
Catalytic activity: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
Recommended name: RING finger and CHY zinc finger domain-containing protein 1
Gene name from HGNC: RCHY1
AlphaFold DB: Q96PM5
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q96PM5
HPA link: https://www.proteinatlas.org/ENSG00000163743-RCHY1
Tissue specificity RNA from HPA: Low tissue specificity
Immune cell specificity: Immune cell enhanced (basophil)
Subcellular summary HPA Localized to the Cytosol In addition localized to the Nucleoplasm, Vesicles
Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable), urothelial cancer (favorable) and colorectal cancer (favorable)
HGNC ID: HGNC:17479
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17479
