Biomarker: C-reactive protein

Histology type: endometrial cancer

Country: British

Region: White British ethnicity

Study type: prospective

Followed up time :

Conclusion: If confirmed in an independent cohort, CRP may offer a simple, low-cost test to refine pre-treatment risk assessment and guide personalised care in endometrial cancer.

Sample type : serum

Sample method: ELISA

Expression pattern : upregulated

Expression elevation: Glasgow prognostic score (GPS) was calculated as follows: women with CRP > 10 mg/L and albumin<35 g/L were allocated GPS = 2; those with CRP > 10 mg/L or albumin<35 g/L were allocated GPS = 1; and those with CRP ≤ 10 mg/L and albumin≥35 g/L were allocated GPS = 0. Modified GPS (mGPS) was calculated as follows: women with CRP > 10 mg/L and albumin<35 g/L were allocated mGPS = 2; women with CRP > 10 mg/L and albumin≥35 g/L were allocated mGPS = 1; and those with CRP < 10 mg/L were allocated mGPS = 0.

Funtion Uniprot: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

UniProt ID: P02741

UniProt Link: https://www.uniprot.org/uniprotkb/P02741/entry

Biological function from UniProt: #Acute phase

Molecular function from UniProt:

Miscellaneous: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.

Recommended name: C-reactive protein

Gene name from HGNC: CRP (PTX1)

AlphaFold DB: P02741

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P02741

HPA link: https://www.proteinatlas.org/ENSG00000132693-CRP

Tissue specificity RNA from HPA: Tissue enriched (liver)

Tissue expression from HPA: Liver - Plasma proteins (mainly)

Single cell type specificity Group enriched (Hepatocytes, Ductal cells)

Immune cell specificity: Not detected in immune cells

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000132693-CRP/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000132693-CRP/pathology/endometrial+cancer

OMIM: 123260

OMIM link2: https://www.omim.org/entry/123260

HGNC ID: HGNC:2367

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2367