Biomarker: B7 homolog 4 (B7-H4)

Histology type: endometrial cancer

Country: China

Region: Beijing

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 596

Subgroup 2 name: negative

Subgroup 2 number: 237

Conclusion: B7-H4 protein expressed highly in endometrial carcinoma tissues, and its high expression is closely related to clinicopathological features, molecular subtype of p53 mutant and NSMP, and the favorable prognosis of patients with low density of CD8+ T lymphocyte immunophenotype endometrial carcinoma.

Sample type : tissue

Sample method: immunohistochemical staining

Statictics: 58 years (range: 25-88 years)

Funtion Uniprot: Triggers NCR3-dependent natural killer cell activation.

Molecular function from UniProt:

Tissue specificity from UniProt: Not detected in any normal tissue tested. Expressed at the surface of several tumor cell lines including T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen-transformed cells (at protein level).

Subcellular UniProt: #Cell membrane #Membrane

Alternative name from UniProt:

Recommended name: Natural cytotoxicity triggering receptor 3 ligand 1

Gene name from HGNC: NCR3LG1

AlphaFold DB: Q68D85

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q68D85

Tissue specificity RNA from HPA: Tissue enhanced (brain, parathyroid gland)

Tissue expression from HPA: Non-specific - Endocytosis (mainly)

Single cell type specificity specificityi Cell type enhanced (Excitatory neurons, Inhibitory neurons, Langerhans cells)

Immune cell specificity: Not detected in immune cells

Pathology link: https://www.proteinatlas.org/ENSG00000188211-NCR3LG1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000188211-NCR3LG1/pathology/endometrial+cancer

OMIM: 613714

OMIM link2: https://www.omim.org/entry/613714