Biomarker: HER2

Histology type: endometrial cancer

Stage: early-stage

Country: Republic of Korea

Region: Gyeongsang

Followed up time :

Subgroup 1 name : High expression

Subgroup 1 number: 19

Subgroup 2 name: Low expression

Subgroup 2 number: 41

Conclusion: The association of VEGFR2 and HER2 expression in early EC was elucidated. This study shows that the measurement of VEGFR2 expression may be useful in the preoperative assessment of EC and suggests the possibility of anti-HER2 therapy for EC.

Sample type : tissue

Sample method: immunohistochemistry

Expression elevation: The pattern of immunohistochemical staining was evaluated; in particular, membranous expression of HER2 and cytoplasmic expression of VEGFR2 were noted. The intensity of stained tumor cells was graded as either high or low. Tumor cells with an intensity higher than that of stromal cells and lymphocytes were graded as high, and those with an intensity the same or lower than that of non-tumor cells were graded as low.

Statictics: Mean ;Range

Cohort age: 51(35-78)

Funtion description: Wound-healing assays revealed that HER2 loss in Ishikawa cells reduced confluence compared to that of control cells.

Funtion Uniprot: Oncoprotein that inhibits PP2A and stabilizes MYC in human malignancies. Promotes anchorage-independent cell growth and tumor formation.

UniProt ID: Q8TCG1

UniProt Link: https://www.uniprot.org/uniprotkb/Q8TCG1/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level).

Subcellular UniProt: #Cytoplasm #Membrane

Alternative name from UniProt:

Miscellaneous: Antibodies against CIP2A are present in sera from many patients with gastric or prostate cancer, suggesting that it may act as a marker for such cancers.

Gene name from HGNC: CIP2A (KIAA1524)

HPA link: https://www.proteinatlas.org/ENSG00000163507-CIP2A

Tissue specificity RNA from HPA: Tissue enhanced (bone marrow, lymphoid tissue)

Tissue expression from HPA: Cytoplasmic and membranous expression in most tissues.

Subcellular summary HPA Located in Plasma membrane, Cytosol (CCD Transcript)

Cancer prognostic summary HPA Prognostic marker in endometrial cancer (unfavorable), renal cancer (unfavorable) and pancreatic cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000163507-CIP2A/tissue

Survival figure legend: Relationship between HER2 expression (assessed by the HercepTest) and survival, mRNA expression and aggressiveness of disease$ Disease-specific survival (DSS) according to the staining index (SI) criteria and apical HER2 loss

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808034/figure/fig1/$ Disease-specific survival (DSS) according to the staining index (SI) criteria and apical HER2 loss.

OMIM: 610643

OMIM link2: https://www.omim.org/entry/610643

HGNC ID: HGNC:29302

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29302