Basic information
Biomarker: NHP2
Histology type: endometrial carcinoma
Cohort characteristics
Country: UK
Region: Liverpool
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
Sample information
Conclusion: Our findings indicate a potential prognostic role for TTAPs in EC, particularly NHP2. Further evaluation of the prognostic and functional role of the examined TTAPs is warranted to develop novel treatment strategies.
Sample type : tissue
Sample method: immunohistochemistry
Expression elevation: Staining intensity (0 = no staining, 1 = weak, 2 = moderate, 3 = strong) was multiplied by percentage of positive cells (0–25% = 1, 25–50% = 2, 51–75% = 3, >75% = 4) to obtain a final score out of 12.
Disease information
Related information
Funtion Uniprot: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
UniProt ID: Q9NX24
UniProt Link: https://www.uniprot.org/uniprotkb/Q9NX24
Biological function from UniProt: #Ribosome biogenesis #rRNA processing
Molecular function from UniProt:
Tissue specificity from UniProt: Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver.
Alternative name from UniProt:
Recommended name: H/ACA ribonucleoprotein complex subunit 2
Gene name from HGNC: NHP2
AlphaFold DB: Q9NX24
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q9NX24
Developmental stage: Transcript peaks at G1/S transition.
HPA link: https://www.proteinatlas.org/ENSG00000145912
Tissue specificity RNA from HPA: Low tissue specificity
Tissue expression from HPA: Non-specific - Mixed function (mainly)
Single cell type specificity Low cell type specificity
Immune cell specificity: Low immune cell specificity
Subcellular summary HPA #Nucleus
Cancer prognostic summary HPA Prognostic marker in endometrial cancer (unfavorable) and liver cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000145912-NHP2/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000145912-NHP2/pathology/endometrial+cancer
