Basic information
Biomarker: citrullinated histone H3
Histology type: endometrial carcinoma
Cohort characteristics
Country: Italy
Region: Rome
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 84 | EC | 63 | healthy | 21 |
Sample information
Conclusion: Our data highlight the occurrence of NETosis in EC and indicate serum cfDNA and citH3 as noninvasive biomarkers of tumor-induced systemic effects in endometrial cancer.
Sample type : tissue
Sample method: immunohistochemistry
Expression elevation: The sample was considered positive with a percentage of staining ≥ 15%. In the second evaluation, a standard point scale for staining intensity was used, with positive slides being scored 1 + , 2 + and 3 + using a positive control slide being taken as 3 + . Strong staining involves > 50% of the cells with score 2 + or 3 + . Moderate staining involves from 25 to 50% of the cells with score 1 + or 2 + . Weak staining involves < 25% of cells with score 1 + .
Disease information
Related information
Molecular function from UniProt:
