Biomarker: PRAME

Histology type: endometrioid and serous endometrial carcinomas

Country: USA

Region: Virginia

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 227

Subgroup 2 name: negative

Subgroup 2 number: 29

Conclusion: The widespread expression of PRAME in endometrial carcinomas suggests this marker should not be interpreted as specific for melanoma in this context. However PRAME may have utility as a predictive biomarker in endometrial cancer, and expansion of testing of PRAME-based therapies to endometrioid and serous endometrial carcinomas may lead to new therapeutic options for these endometrial cancer subtypes.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Funtion Uniprot: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980). The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation (PubMed:21822215). Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis (PubMed:16179254)

UniProt Link: https://www.uniprot.org/uniprotkb/P78395

Biological function from UniProt: #Apoptosis #Differentiation #Growth regulation #Transcription #Transcription regulation #Ubl conjugation pathway

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in testis. Detected in samples of kidney, brain and skin.

Subcellular UniProt: #Cell membrane #Chromosome #Cytoplasm #Golgi apparatus #Membrane #Nucleus

Alternative name from UniProt:

Miscellaneous: Tumor antigen recognized by cytolytic T lymphocytes.

Recommended name: Melanoma antigen preferentially

Gene name from HGNC: PRAME

Induction: Up-regulated in response to interferon gamma (IFNG) treatment and exposure to bacterial PAMPs (pathogen associated molecular patterns).

HPA link: https://www.proteinatlas.org/ENSG00000185686-PRAME

Tissue specificity RNA from HPA: Cytoplasmic expression in seminiferous ducts in testis.

Single cell type specificity Cell type enriched (Spermatogonia)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Localized to the Nucleoplasm In addition localized to the Plasma membrane

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable) and head and neck cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000185686-PRAME/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000185686-PRAME/pathology/endometrial+cancer

OMIM: 606021

OMIM link2: https://www.omim.org/entry/606021

HGNC ID: HGNC:9336

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9336