Biomarker: Suprabasin (SBSN) isoform 2

Histology type: endometrial carcinoma

Country:  Italy

Region: Trieste

Followed up time :

Conclusion: These results suggest that SBSN, specifically isoform 2, in tissue or serum, could be a potential novel biomarker in endometrial cancer.

Sample type : serum

Sample method: 2D-DIGE and mass spectrometry ,Western blotting

Expression pattern : downregulated

Expression elevation: Using gel-based proteomics, we identified 24 candidate biomarkers, considering only spots with a fold change in volume percentage ≥ 1.5 or intensity change ≤ 0.6, which were significantly different between cases and controls (p < 0.05).

UniProt ID: Q6UWP8

UniProt Link: https://www.uniprot.org/uniprotkb/Q6UWP8/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Detected in thymus, uterus and esophagus.

Subcellular UniProt: #Secreted

Recommended name: Suprabasin

Gene name from HGNC: SBSN (HLAR698, UNQ698)

HPA class: Plasma proteins

AlphaFold DB: Q6UWP8

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q6UWP8

Induction: Up-regulated in differentiating keratinocytes

HPA link: https://www.proteinatlas.org/ENSG00000189001-SBSN

Tissue specificity RNA from HPA: Tissue enhanced (esophagus, skin, vagina)

Tissue expression from HPA: Selective membranous expression in squamous epithelia.

Single cell type specificity Suprabasal keratinocytes - Cornification (mainly)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Localized to the Vesicles

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000189001-SBSN/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000189001-SBSN/pathology/endometrial+cancer

OMIM: 609969

OMIM link2: https://www.omim.org/entry/609969

HGNC ID: HGNC:24950

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:24950