Biomarker: CD47

Country: Turkey

Region: Ankara

Followed up time :

Conclusion: TAM count is, therefore, a significant prognostic factor in EC and the CD47 assessment has potential benefit for future clinical use.

Sample type : tissue

Sample method: immunocytochemical staining

Expression pattern : expression

Funtion Uniprot: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection

UniProt ID: Q08722

UniProt Link: https://www.uniprot.org/uniprotkb/Q08722/entry

Biological function from UniProt: #Cell adhesion

Molecular function from UniProt:

Tissue specificity from UniProt: Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Subcellular UniProt: #Cell membrane #Membrane

Alternative name from UniProt:

Recommended name: Leukocyte surface antigen CD47

Gene name from HGNC: CD47 (IAP, MER6, OA3)

CD antigen name: CD47

HPA class: CD markers Transporters

AlphaFold DB: Q08722

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/Q08722

HPA link: https://www.proteinatlas.org/ENSG00000196776-CD47

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic and membranous expression in several tissues.

Single cell type specificity Cell type enhanced (Ductal cells)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Localized to the Plasma membrane In addition localized to the Vesicles

Cancer prognostic summary HPA Prognostic marker in thyroid cancer (favorable), renal cancer (unfavorable) and endometrial cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000196776-CD47/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000196776-CD47/pathology/endometrial+cancer

OMIM: 601028

OMIM link2: https://www.omim.org/entry/601028