Biomarker: Claudin‑9

Histology type: endometrial cancer

Country: Japan

Region: Fukushima

Followed up time :

Subgroup 1 name : CLDN9-high

Subgroup 1 number: 43

Subgroup 2 name: CLDN9-low

Subgroup 2 number: 205

Conclusion: In conclusion, aberrant CLDN9 expression is a predictor of poor prognosis for endometrial cancer and may be utilized in combination with CLDN6 to achieve higher sensitivity.

Sample type : tissue

Sample method: immunocytochemical staining

Expression pattern : aberrant CLDN9 expression

Expression elevation: Immunostaining results were interpreted by two independent pathologists and one gynecologist using a semiquantitative scoring system. The immunostaining reactions were evaluated according to signal intensity (SI; 0, negative; 1, weak; 2, moderate; 3, strong). The receiver operating characteristic (ROC) curve was plotted and analyzed (Fig. S1) to determine the optimal cut-off values of the SI for CLDN9 expression. CLDN6 expression was assessed by the immunoreactive score (IRS) as described previously . p53 mutation was assessed following the most accepted criteria .

Statictics: Mean (SD);Range

Cohort age: 58.2±11.5 ( 30-83)

Funtion Uniprot: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By Similarity (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.

UniProt ID: O95484

UniProt Link: https://www.uniprot.org/uniprotkb/O95484/entry

Biological function from UniProt: #Host-virus interaction

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines

Subcellular UniProt: #Cell junction #Cell membrane #Membrane #Tight junction

Recommended name: Claudin-9

Gene name from HGNC: Claudin-9

AlphaFold DB: 95484

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O95484

Tissue specificity RNA from HPA: Tissue enhanced (brain, pituitary gland)

Single cell type specificity Group enriched (Respiratory ciliated cells, Cholangiocytes, Endometrial ciliated cells, Ductal cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Localized to the Cell Junctions In addition localized to the Vesicles

Cancer prognostic summary HPA Prognostic marker in endometrial cancer (unfavorable) and stomach cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000213937-CLDN9/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000213937-CLDN9/pathology/endometrial+cancer

Survival figure legend: Kaplan-Meier curves

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9521636/figure/f3-ijo-61-5-05425/

Phenotype ID: 619093

Disease: Deafness, autosomal recessive, 116 (DFNB116)

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 615799

OMIM link1: https://www.omim.org/entry/619093

OMIM link2: https://www.omim.org/entry/615799