Basic information
Biomarker: Musashi-1
Cohort characteristics
Country: Germany
Region: Münster
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
Sample information
Conclusion: Musashi-1 knockdown resulted in a strong decrease in endometrial cancer proliferation and a loss of radioresistance, suggesting therapeutic potential.
Expression pattern : Knockdown
Disease information
Subgroup 2 age: 120
Related information
Funtion Uniprot: RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
UniProt ID: O43347
UniProt Link: https://www.uniprot.org/uniprotkb/O43347/entry#names_and_taxonomy
Molecular function from UniProt:
Tissue specificity from UniProt: Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
Subcellular UniProt: #Cytoplasm #Nucleus
Recommended name: RNA-binding protein Musashi homolog 1
Gene name from HGNC: MSI1
AlphaFold DB: O43347
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/O43347
HPA link: O43347
Tissue specificity RNA from HPA: Tissue enriched (retina)
Tissue expression from HPA: Cytoplasmic and nuclear expression in several tissues, including CNS and retina.
Single cell type specificity Cell type enhanced (Rod photoreceptor cells, Muller glia cells, Late spermatids, Cone photoreceptor cells, Early spermatids)
Immune cell specificity: Not detected in immune cells
Subcellular summary HPA Localized to the Nucleoplasm In addition localized to the Cytosol
Cancer prognostic summary HPA Prognostic marker in pancreatic cancer (favorable)
Pathology link: https://www.proteinatlas.org/ENSG00000135097-MSI1/pathology
Pathology endo: https://www.proteinatlas.org/ENSG00000135097-MSI1/pathology/endometrial+cancer
OMIM: 603328
OMIM link2: genhttps://www.omim.org/entry/603328e
HGNC ID: HGNC:7330
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7330
