Basic information
Biomarker: LeY
Cohort characteristics
Country: Germany
Region: Munich
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 234 | EC |
Sample information
Conclusion: This is the first study examining the expression of SLeX, SLeA and LeY in EC, which can serve as additional future prognostic markers.
Sample type : serum
Sample method: immunohistochemistry
Expression pattern : upregulated
Expression elevation: We evaluated the expression of SLeX, SLeA and LeY using the well-established semi-quantitative immunoreactive score (IRS). Therefore, intensity was rated between 0 and 3 (0 = no staining, 1 = low intensity, 2 = moderate intensity, 3 = high intensity). The percentage of the stained tumor cells was subdivided and rated as follows: 0 = 0%, 1 = 1–10%, 2 = 11–50%; 3 = 51–80%; 4 = 81–100%). The values for intensity and stained percentage were multiplied to obtain the IRS. This was done for each spot on the TMA individually. We used the mean of all three scores to assess the final IRS for each patient.
Disease information
Statictics: cutoff<65;cutoff>65
Cohort age: 113;121
Subgroup 2 age: 120
Related information
UniProt Link:
Molecular function from UniProt:
Expression figure legend: Results of LeY staining Normal, non-pathological Ileum tissue stained with Lewis Y as positive control
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587092/figure/Fig6/
Survival figure legend: Survival analysis of SLeA expression Kaplan–Meier analysis of overall survival
Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9587092/figure/Fig5/
