Biomarker: CD39

Histology type: endometrial carcinoma

Country: Spain

Region: Barcelona

Followed up time :

Conclusion: Our results demonstrate that EC are frequently infiltrated by tumor-reactive TILs, and that expression of PD-1hi and CD39 or PD-1hi can be used to select and expand CD8+ and CD4+ tumor-reactive TILs, respectively. In addition, biomarkers preferentially expressed on tumor-reactive TILs, rather than the frequency of CD3+, CD8+ and CD4+ lymphocytes, hold prognostic value suggesting their protective role in antitumor immunity.

Sample method: flow cytometry,fluorescence activated cell sorting (FACS)

Expression pattern : upregulated

Statictics: Mean (SD);Range

Cohort age: 70.36±10.28

Funtion Uniprot: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

UniProt ID: P49961

UniProt Link: https://www.uniprot.org/uniprotkb/P49961/entry

Molecular function from UniProt:

Subcellular UniProt: #Membrane

Alternative name from UniProt:

Catalytic activity: a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 H+ + 2 phosphate

Recommended name: Ectonucleoside triphosphate diphosphohydrolase 1

Gene name from HGNC: ENTPD1 (ATPDase, CD39, NTPDase-1, SPG64)

CD antigen name: CD39

HPA class: CD markers Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets

AlphaFold DB: P49961

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P49961

HPA link: https://www.proteinatlas.org/ENSG00000138185-ENTPD1

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic expression mainly in trophoblastic cells and in endothelial cells. Also expressed in a subset of cells in lymphoid tissue.

Single cell type specificity Cell type enhanced (Microglial cells, Langerhans cells, Plasma cells, Astrocytes, Endothelial cells, Macrophages)

Immune cell specificity: Immune cell enhanced (eosinophil)

Subcellular summary HPA Localized to the Microtubules

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable) and thyroid cancer (favorable)

Pathology link: https://www.proteinatlas.org/ENSG00000138185-ENTPD1/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000138185-ENTPD1/pathology/endometrial+cancer

Survival figure legend: Expression of PD-1hi and CD39 on CD8 TILs enriches tumor recognition and associates with improved survival.

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9806064/figure/F4/

Phenotype ID: 615683

Disease: Spastic paraplegia 64, autosomal recessive (SPG64)

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 601752

OMIM link1: https://www.omim.org/entry/615683

OMIM link2: https://www.omim.org/entry/601752

HGNC ID: HGNC:3363

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3363