Basic information
Biomarker: Citrullinated Histone H3
Histology type: endometrial carcinoma
Cohort characteristics
Country: Italy
Region: Rome
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 84 | EC | 63 | healthy subjects | 21 |
Sample information
Conclusion: Our data highlight the occurrence of NETosis in EC and indicate serum cfDNA and citH3 as noninvasive biomarkers of tumor-induced systemic effects in endometrial cancer.
Sample type : serum
Sample method: ELISA
Expression pattern : detected
Expression elevation: With the first evaluation, the percentage of stained cells out of total infiltrating cells was estimated. The sample was considered positive with a percentage of staining ≥ 15%. In the second evaluation, a standard point scale for staining intensity was used, with positive slides being scored 1 + , 2 + and 3 + using a positive control slide being taken as 3 + . Strong staining involves > 50% of the cells with score 2 + or 3 + . Moderate staining involves from 25 to 50% of the cells with score 1 + or 2 + . Weak staining involves < 25% of cells with score 1 + .
Disease information
Related information
UniProt Link:
Molecular function from UniProt:
Expression figure legend: citH3 staining is present in all endometrial tumor grades.
Expression figure link: https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=9027343_13046_2022_2359_Fig1_HTML.jpg
