Biomarker: HER-2/neu

Histology type: endometrial carcinoma

Country: USA

Region: Minnesota

Followed up time :

Subgroup 1 name : overexpression

Subgroup 1 number: 37

Subgroup 2 name: mild expression;negative

Subgroup 2 number: 144;66

Conclusion: HER-2/neu expression: a major prognostic factor in endometrial cancer.

Sample type : tissue

Sample method: immunoperoxidase technique

Expression pattern : overexpression(each reviewer assigned a score of 0 for no or minimal, 2 for moderate, and 3 for strong staining, and cumulative scores (O-6) were generated for each patient. strong” HER-2/neu staining with scores of 5 or 6; “mild” scores of 2 to 4; and “no” staining, score of zero.

Funtion Uniprot: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.Curated In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.3 Publications

UniProt ID: P04626

UniProt Link: https://www.uniprot.org/uniprotkb/P04626/entry

Biological function from UniProt: Transcription, Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth

Subcellular UniProt: #Cell membrane #Cytoplasm #Endosome #Membrane #Nucleus

Alternative name from UniProt:

Catalytic activity: ATP + L-tyrosyl-[protein] = ADP + H+ + O-phospho-L-tyrosyl-[protein]

Activity regulation: Activated by dimerization. Not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.

Gene name from HGNC: ERBB2 (CD340, HER-2, HER2, NEU, NGL)

CD antigen name: CD340

HPA link: https://www.proteinatlas.org/ENSG00000141736-ERBB2

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Cytoplasmic and membranous expression in most tissues.

Subcellular summary HPA Located in Plasma membrane, Cytosol

Cancer prognostic summary HPA Prognostic marker in renal cancer (favorable), endometrial cancer (unfavorable) and pancreatic cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000163507-CIP2A/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000163507-CIP2A/pathology/endometrial+cancer

OMIM: 137800;164870;167000;

OMIM link2: https://www.omim.org/entry/137800;https://www.omim.org/entry/164870;https://www.omim.org/entry/167000;

Phenotype: GLIOMA SUSCEPTIBILITY 1; GLM1;ERB-B2 RECEPTOR TYROSINE KINASE 2; ERBB2;

HGNC ID: HGNC:3430

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3430