Basic information
Biomarker: colony-stimulating factor 1
Histology type: endometrial carcinoma
Cohort characteristics
Country: Finland
Region: Oulu
Study type: Clinical Trial
Followed up time :
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 183 | untreated endometrial adenocarcinoma | 159 | cytotoxic chemotherapy for recurrent endometrial adenocarcinoma. | 24 |
Sample information
Conclusion: Elevated serum colony-stimulating factor 1 levels were the most accurate indicator of the presence and activity (progression, stabilization, or regression) of primary or recurrent disease. Accuracy was not further enhanced by measurement of CA 125 or the aminoterminal peptide of type III procollagen levels.
Sample type : serum
Sample method: radioimmunoassay
Expression pattern : elevated(>8 ng/ml)
Disease information
Related information
Funtion Uniprot: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
UniProt ID: P04141
UniProt Link: https://www.uniprot.org/uniprotkb/P04141/entry
Molecular function from UniProt:
Subcellular UniProt: #Secreted
Alternative name from UniProt:
Recommended name: Granulocyte-macrophage colony-stimulating factor
Gene name from HGNC: CSF1 (M-CSF, MCSF, MGC31930)
HPA class: Cancer-related genes Candidate cardiovascular disease genes Disease related genes Plasma proteins RAS pathway related proteins
AlphaFold DB: P04141
AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P04141
HPA link: https://www.proteinatlas.org/ENSG00000184371-CSF1
Tissue specificity RNA from HPA: Low tissue specificity
Single cell type specificity Non-specific - Angiogenesis (mainly)
Immune cell specificity: Group enriched (eosinophil, basophil)
Subcellular summary HPA Located in Nuclear bodies, Plasma membrane (Single cell variability)
Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable) and liver cancer (unfavorable)
Pathology link: https://www.proteinatlas.org/ENSG00000184371-CSF1/pathology
Pathology endo: Expression of CSF1 in endometrial cancer - The Human Protein Atlas
OMIM: 138960
OMIM link2: https://www.omim.org/entry/138960
HGNC ID: HGNC:2432
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2432
