Biomarker: sIL-2R

Histology type: endometrial carcinoma

Country: Italy

Region: Università di Pisa

Followed up time :

Subgroup 1 name : elevated serum levels

Subgroup 1 number: 18

Subgroup 2 name: none elevated serum levels

Subgroup 2 number: 17

Conclusion: On the other hand, we observed that sIL-2R was the most sensitive antigen for endometrial cancer; therefore it could represent a new tumor marker for the management of patients with this malignancy.

Sample type : serum

Expression pattern : raised serum concentrations (> or = 50 U/mL)

Funtion Uniprot: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

UniProt ID: P01589

UniProt Link: https://www.uniprot.org/uniprotkb/P01589/entry

Biological function from UniProt: #Immunity

Molecular function from UniProt:

Subcellular UniProt: #Membrane

Alternative name from UniProt:

Recommended name: Interleukin-2 receptor subunit alpha

Gene name from HGNC: IL2RA (CD25, IDDM10, IL2R)

CD antigen name: CD25

HPA class: Cancer-related genes CD markers Disease related genes FDA approved drug targets Human disease related genes Plasma proteins

AlphaFold DB: P01589

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P01589

HPA link: https://www.proteinatlas.org/ENSG00000134460-IL2RA

Tissue specificity RNA from HPA: Tissue enhanced (adipose tissue, lymphoid tissue, urinary bladder)

Tissue expression from HPA: Cytoplasmic expression in a subset of immune cells in several tissues, including lymphoid organs and gastrointestinal tract.

Single cell type specificity Group enriched (monocytes, granulocytes)

Immune cell specificity: Group enriched (T-reg, basophil)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000134460-IL2RA/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000134460-IL2RA/pathology/endometrial+cancer

Phenotype ID: 601942

Disease: Diabetes mellitus, insulin-dependent, 10 (IDDM10);Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41);

Note1: Disease susceptibility is associated with variants affecting the gene represented in this entry;The disease is caused by variants affecting the gene represented in this entry;

OMIM: 147730

OMIM link1: https://www.omim.org/entry/601942;https://www.omim.org/entry/606367;

OMIM link2: https://www.omim.org/entry/147730

HGNC ID: HGNC:6008

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6008