Biomarker: PCNA

Histology type: endometrial carcinoma

Country: Japan

Region: Nagasaki

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 21

Subgroup 2 name: negative

Subgroup 2 number: 28

Conclusion: In conclusion, PCNA protein are related to the proliferation of endometrial carcinoma. So they can be useful factor in making the prognosis.

Sample type : tissue

Sample method: immuno-histochemical staining

Funtion Uniprot: Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (PubMed:35585232). Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways (PubMed:24939902). Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion (PubMed:24695737).

UniProt ID: P12004

UniProt Link: https://www.uniprot.org/uniprotkb/P12004/entry

Biological function from UniProt: #DNA damage #DNA repair #DNA replication #Host-virus interaction

Molecular function from UniProt:

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Miscellaneous: Antibodies against PCNA are present in sera from patients with systemic lupus erythematosus.

Recommended name: Proliferating cell nuclear antigen

Gene name from HGNC: PCNA

HPA class: Cancer-related genes Disease related genes Human disease related genes Plasma proteins

AlphaFold DB: P12004

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P12004

HPA link: https://www.proteinatlas.org/ENSG00000132646-PCNA

Tissue specificity RNA from HPA: Tissue enhanced (bone marrow)

Tissue expression from HPA: Nuclear expression mainly in proliferative cells.

Single cell type specificity Non-specific - Cell cycle regulation (mainly)

Immune cell specificity: Low immune cell specificity

Subcellular summary HPA Located in Nucleoplasm (Single cell variability, CCD Transcript)

Cancer prognostic summary HPA Prognostic marker in renal cancer (unfavorable), cervical cancer (favorable) and liver cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000132646-PCNA/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000132646-PCNA/pathology/endometrial+cancer

Phenotype ID: 615919

Disease: Ataxia-telangiectasia-like disorder 2 (ATLD2)

Note1: The disease is caused by variants affecting the gene represented in this entry

OMIM: 176740

OMIM link1: https://www.omim.org/entry/615919

OMIM link2: https://www.omim.org/entry/176740

HGNC ID: HGNC:8729

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8729