Biomarker: Calretinin

Histology type: rare type

Country: Italy

Region: Milan

Followed up time :

Conclusion: Calretinin is a very useful marker for positive identification of normal and tumor mesothelial cells in serous effusions.

Sample type : cytology

Sample method: immunostained

Expression pattern : expression

Expression elevation: In all cases the two observers gave concordant evaluations of the staining results, with regard both to staining intensity (strong and weak) and percentage of immunostained cells (< 10%, 10–50%, 50–75%, > 75%), counting all the tumor cells of the cytocentrifuge preparations.

Funtion Uniprot: Calretinin is a calcium-binding protein which is abundant in auditory neurons.

UniProt ID: P22676

UniProt Link: https://www.uniprot.org/uniprotkb/P22676/entry

Molecular function from UniProt:

Tissue specificity from UniProt: Brain.

Alternative name from UniProt:

Recommended name: Calretinin

Gene name from HGNC: CALB2 (CAL2)

HPA class: Plasma proteins Transporters

AlphaFold DB: P22676

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P22676

HPA link: https://www.proteinatlas.org/ENSG00000172137-CALB2

Tissue specificity RNA from HPA: Tissue enhanced (adipose tissue, brain, breast)

Tissue expression from HPA: Cytoplasmic expression in several tissues and cells, including adipose tissue, brain, fallopian tube, endocrine pancreas and Leydig cells.

Single cell type specificity Cell type enhanced (granulocytes, Exocrine glandular cells, Theca cells, Granulosa cells)

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Cytosol

Cancer prognostic summary HPA Prognostic marker in colorectal cancer (unfavorable)

Pathology link: https://www.proteinatlas.org/ENSG00000172137-CALB2/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000172137-CALB2/pathology/endometrial+cancer

OMIM: 114051

OMIM link2: https://www.omim.org/entry/114051

HGNC ID: HGNC:1435

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1435