Biomarker: c-Jun

Histology type: endometrial carcinoma

Country: Japan

Region: Hirosaki

Followed up time :

Subgroup 1 name : positive

Subgroup 1 number: 28

Subgroup 2 name: negative

Subgroup 2 number: 35

Conclusion: These results suggest that the expressions of GST-pi and c-Jun may reflect the metastatic potential of endometrial carcinomas and that their expressions of endometrial carcinoma may be useful as a prognostic indicator for predictive testing.

Sample type : tissue

Sample method: immunohistochemistry

Expression pattern : expression

Expression elevation: Stained sections were compared with controls, and carcinomas in which 30% or more of the component cells were stained for GST-p or oncogene products were evaluated as positive, whereas tissues consisting of less than 30% stained cells were counted as negative

Funtion Uniprot: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306).

UniProt ID: P05412

UniProt Link: https://www.uniprot.org/uniprotkb/P05412/entry

Biological function from UniProt: #Transcription #Transcription regulation

Molecular function from UniProt:

Tissue specificity from UniProt: Expressed in the developing and adult prostate and prostate cancer cells.

Subcellular UniProt: #Nucleus

Alternative name from UniProt:

Recommended name: Transcription factor Jun

Gene name from HGNC: JUN (AP-1, c-Jun)

HPA class: Cancer-related genes FDA approved drug targets Transcription factors

AlphaFold DB: P05412

AlphaFold Link: https://alphafold.ebi.ac.uk/entry/P05412

HPA link: https://www.proteinatlas.org/ENSG00000177606-JUN

Tissue specificity RNA from HPA: Low tissue specificity

Tissue expression from HPA: Nuclear expression in several tissues, mostly in a fraction of the cells.

Single cell type specificity Low cell type specificity

Immune cell specificity: Not detected in immune cells

Subcellular summary HPA Located in Nucleoplasm (Single cell variability, CCD Protein)

Cancer prognostic summary HPA Gene product is not prognostic

Pathology link: https://www.proteinatlas.org/ENSG00000177606-JUN/pathology

Pathology endo: https://www.proteinatlas.org/ENSG00000177606-JUN/pathology/endometrial+cancer

OMIM: 165160

OMIM link2: https://www.omim.org/entry/165160

HGNC ID: HGNC:6204

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6204